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TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist
Diffuse intrinsic pontine gliomas (DIPGs) are high-grade tumors of the brainstem that often occur in children, with a median overall survival of less than one year. Given the fact that DIPGs are resistant to chemotherapy and are not amenable to surgical resection, it is imperative to develop new the...
Autores principales: | Xu, Cheng, Liu, Heng, Pirozzi, Christopher J., Chen, Lee H., Greer, Paula K., Diplas, Bill H., Zhang, Liwei, Waitkus, Matthew S., He, Yiping, Yan, Hai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565061/ https://www.ncbi.nlm.nih.gov/pubmed/34732238 http://dx.doi.org/10.1186/s40478-021-01270-y |
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