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Structural basis of chromatin regulation by histone variant H2A.Z

The importance of histone variant H2A.Z in transcription regulation has been well established, yet its mechanism-of-action remains enigmatic. Conflicting evidence exists in support of both an activating and a repressive role of H2A.Z in transcription. Here we report cryo-electron microscopy (cryo-EM...

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Detalles Bibliográficos
Autores principales: Lewis, Tyler S, Sokolova, Vladyslava, Jung, Harry, Ng, Honkit, Tan, Dongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565303/
https://www.ncbi.nlm.nih.gov/pubmed/34643712
http://dx.doi.org/10.1093/nar/gkab907