Single molecule characterization of the binding kinetics of a transcription factor and its modulation by DNA sequence and methylation

The interaction of transcription factors with their response elements in DNA is emerging as a highly complex process, whose characterization requires measuring the full distribution of binding and dissociation times in a well-controlled assay. Here, we present a single-molecule assay that exploits t...

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Detalles Bibliográficos
Autores principales: Khamis, Hadeel, Rudnizky, Sergei, Melamed, Philippa, Kaplan, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565314/
https://www.ncbi.nlm.nih.gov/pubmed/34606618
http://dx.doi.org/10.1093/nar/gkab843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565314/
https://www.ncbi.nlm.nih.gov/pubmed/34606618
http://dx.doi.org/10.1093/nar/gkab843

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