Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation

Binding and unbinding of transcription factors to DNA are kinetically controlled to regulate the transcriptional outcome. Control of the release of the transcription factor NF-κB from DNA is achieved through accelerated dissociation by the inhibitor protein IκBα. Using single-molecule FRET, we obser...

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Detalles Bibliográficos
Autores principales: Chen, Wei, Lu, Wei, Wolynes, Peter G, Komives, Elizabeth A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565325/
https://www.ncbi.nlm.nih.gov/pubmed/34614173
http://dx.doi.org/10.1093/nar/gkab874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565325/
https://www.ncbi.nlm.nih.gov/pubmed/34614173
http://dx.doi.org/10.1093/nar/gkab874

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