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Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation
Binding and unbinding of transcription factors to DNA are kinetically controlled to regulate the transcriptional outcome. Control of the release of the transcription factor NF-κB from DNA is achieved through accelerated dissociation by the inhibitor protein IκBα. Using single-molecule FRET, we obser...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565325/ https://www.ncbi.nlm.nih.gov/pubmed/34614173 http://dx.doi.org/10.1093/nar/gkab874 |