Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease

Long interspersed nuclear element-1 (L1) is an autonomous non-LTR retrotransposon comprising ∼20% of the human genome. L1 self-propagation causes genomic instability and is strongly associated with aging, cancer and other diseases. The endonuclease domain of L1’s ORFp2 protein (L1-EN) initiates de n...

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Detalles Bibliográficos
Autores principales: Miller, Ian, Totrov, Max, Korotchkina, Lioubov, Kazyulkin, Denis N, Gudkov, Andrei V, Korolev, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565326/
https://www.ncbi.nlm.nih.gov/pubmed/34554261
http://dx.doi.org/10.1093/nar/gkab826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565326/
https://www.ncbi.nlm.nih.gov/pubmed/34554261
http://dx.doi.org/10.1093/nar/gkab826

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