A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity

Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly poorly understood. Here, we studied the genome-wide...

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Detalles Bibliográficos
Autores principales: McCann, Alex J, Lou, Jieqiong, Moustaqil, Mehdi, Graus, Matthew S, Blum, Ailisa, Fontaine, Frank, Liu, Hui, Luu, Winnie, Rudolffi-Soto, Paulina, Koopman, Peter, Sierecki, Emma, Gambin, Yann, Meunier, Frédéric A, Liu, Zhe, Hinde, Elizabeth, Francois, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565327/
https://www.ncbi.nlm.nih.gov/pubmed/34570228
http://dx.doi.org/10.1093/nar/gkab820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565327/
https://www.ncbi.nlm.nih.gov/pubmed/34570228
http://dx.doi.org/10.1093/nar/gkab820

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