The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma

Dysregulated metabolism is a hallmark of cancer that manifests through alterations in bioenergetic and biosynthetic pathways to enable tumor cell proliferation and survival. Tumor cells exhibit high rates of glycolysis, a phenomenon known as the Warburg effect, and an increase in glutamine consumpti...

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Detalles Bibliográficos
Autores principales: Emberley, Ethan, Pan, Alison, Chen, Jason, Dang, Rosalyn, Gross, Matt, Huang, Tony, Li, Weiqun, MacKinnon, Andrew, Singh, Devansh, Sotirovska, Natalija, Steggerda, Susanne M., Wang, Tracy, Parlati, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565744/
https://www.ncbi.nlm.nih.gov/pubmed/34731180
http://dx.doi.org/10.1371/journal.pone.0259241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565744/
https://www.ncbi.nlm.nih.gov/pubmed/34731180
http://dx.doi.org/10.1371/journal.pone.0259241

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