Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency

Although many long non-coding RNAs (lncRNAs) exhibit lineage-specific expression, the vast majority remain functionally uncharacterized in the context of development. Here, we report the first described human embryonic stem cell (hESC) lines to repress (CRISPRi) or activate (CRISPRa) transcription d...

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Detalles Bibliográficos
Autores principales: Haswell, Jeffrey R., Mattioli, Kaia, Gerhardinger, Chiara, Maass, Philipp G., Foster, Daniel J., Peinado, Paola, Wang, Xiaofeng, Medina, Pedro P., Rinn, John L., Slack, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565776/
https://www.ncbi.nlm.nih.gov/pubmed/34731163
http://dx.doi.org/10.1371/journal.pone.0252848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565776/
https://www.ncbi.nlm.nih.gov/pubmed/34731163
http://dx.doi.org/10.1371/journal.pone.0252848

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