Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens

HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion peptide (FP). Selection criteria included i) high expre...

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Detalles Bibliográficos
Autores principales: Crooks, Emma T., Almanza, Francisco, D’Addabbo, Alessio, Duggan, Erika, Zhang, Jinsong, Wagh, Kshitij, Mou, Huihui, Allen, Joel D., Thomas, Alyssa, Osawa, Keiko, Korber, Bette T., Tsybovsky, Yaroslav, Cale, Evan, Nolan, John, Crispin, Max, Verkoczy, Laurent K., Binley, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565784/
https://www.ncbi.nlm.nih.gov/pubmed/34679128
http://dx.doi.org/10.1371/journal.ppat.1009807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565784/
https://www.ncbi.nlm.nih.gov/pubmed/34679128
http://dx.doi.org/10.1371/journal.ppat.1009807

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