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Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies
A growing body of evidence supports the important role of molecular charge on antibody pharmacokinetics (PK), yet a quantitative description of the effect of charge on systemic and tissue disposition of antibodies is still lacking. Consequently, we have systematically engineered complementarity-dete...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565835/ https://www.ncbi.nlm.nih.gov/pubmed/34711143 http://dx.doi.org/10.1080/19420862.2021.1993769 |