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Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies

A growing body of evidence supports the important role of molecular charge on antibody pharmacokinetics (PK), yet a quantitative description of the effect of charge on systemic and tissue disposition of antibodies is still lacking. Consequently, we have systematically engineered complementarity-dete...

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Detalles Bibliográficos
Autores principales:	Liu, Shufang, Verma, Ashwni, Kettenberger, Hubert, Richter, Wolfgang F., Shah, Dhaval K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565835/ https://www.ncbi.nlm.nih.gov/pubmed/34711143 http://dx.doi.org/10.1080/19420862.2021.1993769

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