Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common C(H)2 cleavages in IgGs and IgG-like bispecific antibodies

Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in C(H)2 domains linked by intrachain disulfide bonds are common and can be detected by reduce...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Mingyan, Jiao, Yang, Parthemore, Conner, Korman, Samuel, Ma, Jiao, Hunter, Alan, Kilby, Greg, Chen, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565840/
https://www.ncbi.nlm.nih.gov/pubmed/34719342
http://dx.doi.org/10.1080/19420862.2021.1981806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565840/
https://www.ncbi.nlm.nih.gov/pubmed/34719342
http://dx.doi.org/10.1080/19420862.2021.1981806

Ejemplares similares