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Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common C(H)2 cleavages in IgGs and IgG-like bispecific antibodies
Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in C(H)2 domains linked by intrachain disulfide bonds are common and can be detected by reduce...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565840/ https://www.ncbi.nlm.nih.gov/pubmed/34719342 http://dx.doi.org/10.1080/19420862.2021.1981806 |