Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis

Recently, large-scale human genetics studies identified a rare coding variant in the ABI3 gene that is associated with an increased risk of Alzheimer’s disease (AD). However, pathways by which ABI3 contributes to the pathogenesis of AD are unknown. To address this question, we determined whether los...

Descripción completa

Detalles Bibliográficos
Autores principales: Karahan, Hande, Smith, Daniel C., Kim, Byungwook, Dabin, Luke C., Al-Amin, Md Mamun, Wijeratne, H. R. Sagara, Pennington, Taylor, Viana di Prisco, Gonzalo, McCord, Brianne, Lin, Peter Bor-chian, Li, Yuxin, Peng, Junmin, Oblak, Adrian L., Chu, Shaoyou, Atwood, Brady K., Kim, Jungsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565913/
https://www.ncbi.nlm.nih.gov/pubmed/34731000
http://dx.doi.org/10.1126/sciadv.abe3954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565913/
https://www.ncbi.nlm.nih.gov/pubmed/34731000
http://dx.doi.org/10.1126/sciadv.abe3954

Ejemplares similares