Melatonin potentiates the cytotoxic effect of Neratinib in HER2(+) breast cancer through promoting endocytosis and lysosomal degradation of HER2

Complete blockade of the HER2 protein itself and HER signaling network is critical to achieving effective HER2-targeted therapies. Despite the success of HER2-targeted therapies, the diseases will relapse in a significant fraction of patients with HER2(+) breast cancers. How to improve the therapeut...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Zundong, Sang, Xiaolin, Wang, Min, Liu, Yichao, Liu, Jiao, Wang, Xuefei, Liu, Pixu, Cheng, Hailing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566236/
https://www.ncbi.nlm.nih.gov/pubmed/34556812
http://dx.doi.org/10.1038/s41388-021-02015-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566236/
https://www.ncbi.nlm.nih.gov/pubmed/34556812
http://dx.doi.org/10.1038/s41388-021-02015-w

Ejemplares similares