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Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12

OBJECTIVES: Gout, caused by chronic elevation of serum uric acid levels, is the commonest form of inflammatory arthritis. The causative effect of common and rare variants of ATP-binding cassette transporter G2 (ABCG2/BCRP) on gout risk has been studied, but little attention has been paid to the effe...

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Detalles Bibliográficos
Autores principales: Toyoda, Yu, Kawamura, Yusuke, Nakayama, Akiyoshi, Nakaoka, Hirofumi, Higashino, Toshihide, Shimizu, Seiko, Ooyama, Hiroshi, Morimoto, Keito, Uchida, Naohiro, Shigesawa, Ryuichiro, Takeuchi, Kenji, Inoue, Ituro, Ichida, Kimiyoshi, Suzuki, Hiroshi, Shinomiya, Nariyoshi, Takada, Tappei, Matsuo, Hirotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566256/
https://www.ncbi.nlm.nih.gov/pubmed/33821957
http://dx.doi.org/10.1093/rheumatology/keab327