Lead optimization of novel quinolone chalcone compounds by a structure–activity relationship (SAR) study to increase efficacy and metabolic stability

Many agents targeting the colchicine binding site in tubulin have been developed as potential anticancer agents. However, none has successfully made it to the clinic, due mainly to dose limiting toxicities and the emergence of multi-drug resistance. Chalcones targeting tubulin have been proposed as...

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Detalles Bibliográficos
Autores principales: Knockleby, James, Djigo, Aïcha Dede, Lindamulage, Indeewari Kalhari, Karthikeyan, Chandrabose, Trivedi, Piyush, Lee, Hoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566451/
https://www.ncbi.nlm.nih.gov/pubmed/34732782
http://dx.doi.org/10.1038/s41598-021-01058-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566451/
https://www.ncbi.nlm.nih.gov/pubmed/34732782
http://dx.doi.org/10.1038/s41598-021-01058-z

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