Thioredoxin-1 mediates neuroprotection of Schisanhenol against MPP(+)-induced apoptosis via suppression of ASK1-P38-NF-κB pathway in SH-SY5Y cells

Oxidative stress-induced dopaminergic neuronal loss and apoptosis play a crucial role in the pathogenesis of Parkinson’s disease (PD), and as a vital antioxidant protein, thioredoxin (Trx) exerts neuroprotection against PD. In this study, we investigated the effect of Schisanhenol (Sal), an active c...

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Detalles Bibliográficos
Autores principales: Yang, Hongyan, Li, Libo, Jiao, Yu, Zhang, Yuanliang, Wang, Yuhua, Zhu, Kunjie, Sun, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566484/
https://www.ncbi.nlm.nih.gov/pubmed/34732784
http://dx.doi.org/10.1038/s41598-021-01000-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566484/
https://www.ncbi.nlm.nih.gov/pubmed/34732784
http://dx.doi.org/10.1038/s41598-021-01000-3

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