Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation

Cancers develop from the accumulation of somatic mutations, yet it remains unclear how oncogenic lesions cooperate to drive cancer progression. Using a mouse model harboring NRas(G12D) and EZH2 mutations that recapitulates leukemic progression, we employ single-cell transcriptomic profiling to map c...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yuxuan, Gu, Zhimin, Cao, Hui, Kaphle, Pranita, Lyu, Junhua, Zhang, Yuannyu, Hu, Wenhuo, Chung, Stephen S., Dickerson, Kathryn E., Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566485/
https://www.ncbi.nlm.nih.gov/pubmed/34732703
http://dx.doi.org/10.1038/s41467-021-26582-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566485/
https://www.ncbi.nlm.nih.gov/pubmed/34732703
http://dx.doi.org/10.1038/s41467-021-26582-4

Ejemplares similares