HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape

Transcription modulated by the circadian clock is diverse across cell types, underlying circadian control of peripheral metabolism and its observed perturbation in human diseases. We report that knockout of the lineage-specifying Hnf4a gene in mouse liver causes associated reductions in the genome-w...

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Detalles Bibliográficos
Autores principales: Qu, Meng, Qu, Han, Jia, Zhenyu, Kay, Steve A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566521/
https://www.ncbi.nlm.nih.gov/pubmed/34732735
http://dx.doi.org/10.1038/s41467-021-26567-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566521/
https://www.ncbi.nlm.nih.gov/pubmed/34732735
http://dx.doi.org/10.1038/s41467-021-26567-3

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