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Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis

Mammalian nephron endowment is determined by the coordinated cessation of nephrogenesis in independent niches. Here we report that translatome analysis in Tsc1(+/−) nephron progenitor cells from mice with elevated nephron numbers reveals how differential translation of Wnt antagonists over agonists...

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Detalles Bibliográficos
Autores principales: Jarmas, Alison E., Brunskill, Eric W., Chaturvedi, Praneet, Salomonis, Nathan, Kopan, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566581/
https://www.ncbi.nlm.nih.gov/pubmed/34732708
http://dx.doi.org/10.1038/s41467-021-26626-9