Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

In vitro phagocytosis of Mycobacterium tuberculosis (Mtb) aggregates (Mtb-AG), rather than similar numbers of single bacilli (Mtb-SC), induces host macrophage death and favors bacterial growth. Here, we examined whether aggregation contributes to enhanced Mtb pathogenicity in vivo in rabbit lungs. R...

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Detalles Bibliográficos
Autores principales: Kolloli, Afsal, Kumar, Ranjeet, Singh, Pooja, Narang, Anshika, Kaplan, Gilla, Sigal, Alex, Subbian, Selvakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566596/
https://www.ncbi.nlm.nih.gov/pubmed/34732811
http://dx.doi.org/10.1038/s42003-021-02769-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566596/
https://www.ncbi.nlm.nih.gov/pubmed/34732811
http://dx.doi.org/10.1038/s42003-021-02769-9

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