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Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

In vitro phagocytosis of Mycobacterium tuberculosis (Mtb) aggregates (Mtb-AG), rather than similar numbers of single bacilli (Mtb-SC), induces host macrophage death and favors bacterial growth. Here, we examined whether aggregation contributes to enhanced Mtb pathogenicity in vivo in rabbit lungs. R...

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Detalles Bibliográficos
Autores principales:	Kolloli, Afsal, Kumar, Ranjeet, Singh, Pooja, Narang, Anshika, Kaplan, Gilla, Sigal, Alex, Subbian, Selvakumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566596/ https://www.ncbi.nlm.nih.gov/pubmed/34732811 http://dx.doi.org/10.1038/s42003-021-02769-9

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