Microbiota and Ocular Diseases

Recent advances have identified significant associations between the composition and function of the gut microbiota and various disorders in organ systems other than the digestive tract. Utilizing next-generation sequencing and multiomics approaches, the microbial community that possibly impacts ocu...

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Autores principales: Xue, Wei, Li, Jing Jing, Zou, Yanli, Zou, Bin, Wei, Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566696/
https://www.ncbi.nlm.nih.gov/pubmed/34746029
http://dx.doi.org/10.3389/fcimb.2021.759333
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author Xue, Wei
Li, Jing Jing
Zou, Yanli
Zou, Bin
Wei, Lai
author_facet Xue, Wei
Li, Jing Jing
Zou, Yanli
Zou, Bin
Wei, Lai
author_sort Xue, Wei
collection PubMed
description Recent advances have identified significant associations between the composition and function of the gut microbiota and various disorders in organ systems other than the digestive tract. Utilizing next-generation sequencing and multiomics approaches, the microbial community that possibly impacts ocular disease has been identified. This review provides an overview of the literature on approaches to microbiota analysis and the roles of commensal microbes in ophthalmic diseases, including autoimmune uveitis, age-related macular degeneration, glaucoma, and other ocular disorders. In addition, this review discusses the hypothesis of the “gut-eye axis” and evaluates the therapeutic potential of targeting commensal microbiota to alleviate ocular inflammation.
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spelling pubmed-85666962021-11-05 Microbiota and Ocular Diseases Xue, Wei Li, Jing Jing Zou, Yanli Zou, Bin Wei, Lai Front Cell Infect Microbiol Cellular and Infection Microbiology Recent advances have identified significant associations between the composition and function of the gut microbiota and various disorders in organ systems other than the digestive tract. Utilizing next-generation sequencing and multiomics approaches, the microbial community that possibly impacts ocular disease has been identified. This review provides an overview of the literature on approaches to microbiota analysis and the roles of commensal microbes in ophthalmic diseases, including autoimmune uveitis, age-related macular degeneration, glaucoma, and other ocular disorders. In addition, this review discusses the hypothesis of the “gut-eye axis” and evaluates the therapeutic potential of targeting commensal microbiota to alleviate ocular inflammation. Frontiers Media S.A. 2021-10-21 /pmc/articles/PMC8566696/ /pubmed/34746029 http://dx.doi.org/10.3389/fcimb.2021.759333 Text en Copyright © 2021 Xue, Li, Zou, Zou and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Xue, Wei
Li, Jing Jing
Zou, Yanli
Zou, Bin
Wei, Lai
Microbiota and Ocular Diseases
title Microbiota and Ocular Diseases
title_full Microbiota and Ocular Diseases
title_fullStr Microbiota and Ocular Diseases
title_full_unstemmed Microbiota and Ocular Diseases
title_short Microbiota and Ocular Diseases
title_sort microbiota and ocular diseases
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566696/
https://www.ncbi.nlm.nih.gov/pubmed/34746029
http://dx.doi.org/10.3389/fcimb.2021.759333
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