Microbiota and Ocular Diseases
Recent advances have identified significant associations between the composition and function of the gut microbiota and various disorders in organ systems other than the digestive tract. Utilizing next-generation sequencing and multiomics approaches, the microbial community that possibly impacts ocu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566696/ https://www.ncbi.nlm.nih.gov/pubmed/34746029 http://dx.doi.org/10.3389/fcimb.2021.759333 |
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author | Xue, Wei Li, Jing Jing Zou, Yanli Zou, Bin Wei, Lai |
author_facet | Xue, Wei Li, Jing Jing Zou, Yanli Zou, Bin Wei, Lai |
author_sort | Xue, Wei |
collection | PubMed |
description | Recent advances have identified significant associations between the composition and function of the gut microbiota and various disorders in organ systems other than the digestive tract. Utilizing next-generation sequencing and multiomics approaches, the microbial community that possibly impacts ocular disease has been identified. This review provides an overview of the literature on approaches to microbiota analysis and the roles of commensal microbes in ophthalmic diseases, including autoimmune uveitis, age-related macular degeneration, glaucoma, and other ocular disorders. In addition, this review discusses the hypothesis of the “gut-eye axis” and evaluates the therapeutic potential of targeting commensal microbiota to alleviate ocular inflammation. |
format | Online Article Text |
id | pubmed-8566696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85666962021-11-05 Microbiota and Ocular Diseases Xue, Wei Li, Jing Jing Zou, Yanli Zou, Bin Wei, Lai Front Cell Infect Microbiol Cellular and Infection Microbiology Recent advances have identified significant associations between the composition and function of the gut microbiota and various disorders in organ systems other than the digestive tract. Utilizing next-generation sequencing and multiomics approaches, the microbial community that possibly impacts ocular disease has been identified. This review provides an overview of the literature on approaches to microbiota analysis and the roles of commensal microbes in ophthalmic diseases, including autoimmune uveitis, age-related macular degeneration, glaucoma, and other ocular disorders. In addition, this review discusses the hypothesis of the “gut-eye axis” and evaluates the therapeutic potential of targeting commensal microbiota to alleviate ocular inflammation. Frontiers Media S.A. 2021-10-21 /pmc/articles/PMC8566696/ /pubmed/34746029 http://dx.doi.org/10.3389/fcimb.2021.759333 Text en Copyright © 2021 Xue, Li, Zou, Zou and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Xue, Wei Li, Jing Jing Zou, Yanli Zou, Bin Wei, Lai Microbiota and Ocular Diseases |
title | Microbiota and Ocular Diseases |
title_full | Microbiota and Ocular Diseases |
title_fullStr | Microbiota and Ocular Diseases |
title_full_unstemmed | Microbiota and Ocular Diseases |
title_short | Microbiota and Ocular Diseases |
title_sort | microbiota and ocular diseases |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566696/ https://www.ncbi.nlm.nih.gov/pubmed/34746029 http://dx.doi.org/10.3389/fcimb.2021.759333 |
work_keys_str_mv | AT xuewei microbiotaandoculardiseases AT lijingjing microbiotaandoculardiseases AT zouyanli microbiotaandoculardiseases AT zoubin microbiotaandoculardiseases AT weilai microbiotaandoculardiseases |