ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid–liquid phase separation and liquid-to-solid transition

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the accumulation of protein aggregates in motor neurons. Recent discoveries of genetic mutations in ALS patients promoted research into the complex molecular mechanisms underlying ALS. FUS (fused in sarcoma) is a rep...

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Detalles Bibliográficos
Autores principales: Ishiguro, Akira, Lu, Jun, Ozawa, Daisaku, Nagai, Yoshitaka, Ishihama, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567205/
https://www.ncbi.nlm.nih.gov/pubmed/34624313
http://dx.doi.org/10.1016/j.jbc.2021.101284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567205/
https://www.ncbi.nlm.nih.gov/pubmed/34624313
http://dx.doi.org/10.1016/j.jbc.2021.101284

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