Structural basis for the specificity of PPM1H phosphatase for Rab GTPases

LRRK2 serine/threonine kinase is associated with inherited Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their switch 2 motif to control their interactions with effectors. Recent work has shown that the metal‐dependent protein phosphatase PPM1H counteracts LRRK2 by dephosp...

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Detalles Bibliográficos
Autores principales: Waschbüsch, Dieter, Berndsen, Kerryn, Lis, Pawel, Knebel, Axel, Lam, Yuko PY, Alessi, Dario R, Khan, Amir R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567228/
https://www.ncbi.nlm.nih.gov/pubmed/34580980
http://dx.doi.org/10.15252/embr.202152675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567228/
https://www.ncbi.nlm.nih.gov/pubmed/34580980
http://dx.doi.org/10.15252/embr.202152675

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