Cargando…
Degradation of WTAP blocks antiviral responses by reducing the m(6)A levels of IRF3 and IFNAR1 mRNA
N (6)‐methyladenosine (m(6)A) is a chemical modification present in multiple RNA species and is most abundant in mRNAs. Studies on m(6)A reveal its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. Although some recent discoveries indi...
Autores principales: | Ge, Yong, Ling, Tao, Wang, Yao, Jia, Xin, Xie, Xiongmei, Chen, Rong, Chen, Shangwu, Yuan, Shaochun, Xu, Anlong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567250/ https://www.ncbi.nlm.nih.gov/pubmed/34467630 http://dx.doi.org/10.15252/embr.202052101 |
Ejemplares similares
-
IFNAR1 Is a Predictor for Overall Survival in Colorectal Cancer and Its mRNA Expression Correlated With IRF7 But Not TLR9
por: Chang, Liang-Che, et al.
Publicado: (2014) -
Feline calicivirus strain 2280 p30 antagonizes type I interferon-mediated antiviral innate immunity through directly degrading IFNAR1 mRNA
por: Tian, Jin, et al.
Publicado: (2020) -
The role of alternative polyadenylation in the antiviral innate immune response
por: Jia, Xin, et al.
Publicado: (2017) -
WTAP-mediated N(6)-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
por: Lan, Jianzi, et al.
Publicado: (2022) -
The RNA m(6)A writer WTAP in diseases: structure, roles, and mechanisms
por: Huang, Qibo, et al.
Publicado: (2022)