Codon pair optimization (CPO): a software tool for synthetic gene design based on codon pair bias to improve the expression of recombinant proteins in Pichia pastoris

BACKGROUND: Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias. However, codon-pair contexts have a profound effect on translation efficiency by influenci...

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Detalles Bibliográficos
Autores principales: Huang, Yide, Lin, Ting, Lu, Lingfang, Cai, Fan, Lin, Jie, Jiang, Yu′e, Lin, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567542/
https://www.ncbi.nlm.nih.gov/pubmed/34736476
http://dx.doi.org/10.1186/s12934-021-01696-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567542/
https://www.ncbi.nlm.nih.gov/pubmed/34736476
http://dx.doi.org/10.1186/s12934-021-01696-y

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