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Codon pair optimization (CPO): a software tool for synthetic gene design based on codon pair bias to improve the expression of recombinant proteins in Pichia pastoris

BACKGROUND: Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias. However, codon-pair contexts have a profound effect on translation efficiency by influenci...

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Detalles Bibliográficos
Autores principales:	Huang, Yide, Lin, Ting, Lu, Lingfang, Cai, Fan, Lin, Jie, Jiang, Yu′e, Lin, Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567542/ https://www.ncbi.nlm.nih.gov/pubmed/34736476 http://dx.doi.org/10.1186/s12934-021-01696-y

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