Cargando…

Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene

Cycline-dependent kinase 4 (CDK4), an enzyme of the cycline dependent or Ser/Thr protein kinase family, plays a role in cell cycle progression (G1 phase) by phosphorylating a tumor suppressor protein called pRB. Alteration of this enzyme due to missense mutation/ nonsynonymous single nucleotide poly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Islam, Rahatul, Rahaman, Mashiur, Hoque, Hammadul, Hasan, Nazmul, Prodhan, Shamsul H., Ruhama, Asfia, Jewel, Nurnabi Azad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568134/ https://www.ncbi.nlm.nih.gov/pubmed/34735543 http://dx.doi.org/10.1371/journal.pone.0259691

Ejemplares similares

Implementation of in silico methods to predict common epitopes for vaccine development against Chikungunya and Mayaro viruses
por: Hoque, Hammadul, et al.
Publicado: (2021)

Ectopic expression of Vigna radiata's vacuolar Na(+)/H(+) antiporter gene (VrNHX1) in indica rice (Oryza sativa L.)
por: Hasan, Md. Nazmul, et al.
Publicado: (2022)

Characterization of transcription factor MYB59 and expression profiling in response to low K(+) and NO(3)(−) in indica rice (Oryza sativa L.)
por: Islam, Md. Qamrul, et al.
Publicado: (2021)

Identification, characterization of Apyrase (APY) gene family in rice (Oryza sativa) and analysis of the expression pattern under various stress conditions
por: Chowdhury, Aniqua Tasnim, et al.
Publicado: (2023)

Development of partial abiotic stress tolerant Citrus reticulata Blanco and Citrus sinensis (L.) Osbeck through Agrobacterium-mediated transformation method
por: Hasan, Nazmul, et al.
Publicado: (2019)

Genetic variability analysis of partially salt tolerant local and inbred rice (Oryza sativa L.) through molecular markers
por: Mazumder, Sonia Rani, et al.
Publicado: (2020)

Prediction of Deleterious Nonsynonymous Single-Nucleotide Polymorphism for Human Diseases
por: Wu, Jiaxin, et al.
Publicado: (2013)

nsSNPAnalyzer: identifying disease-associated nonsynonymous single nucleotide polymorphisms
por: Bao, Lei, et al.
Publicado: (2005)

Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in WFS1
por: Qian, Xuli, et al.
Publicado: (2015)

EFIN: predicting the functional impact of nonsynonymous single nucleotide polymorphisms in human genome
por: Zeng, Shuai, et al.
Publicado: (2014)

In silico analysis for determining the deleterious nonsynonymous single nucleotide polymorphisms of BRCA genes
por: Yadegari, Fatemeh, et al.
Publicado: (2019)

An In Silico Evaluation of Deleterious Nonsynonymous Single Nucleotide Polymorphisms in the ErbB3 Oncogene
por: Raghav, Dhwani, et al.
Publicado: (2013)

A systematic review of nonsynonymous single nucleotide polymorphisms in the renin–angiotensin–aldosterone system
por: Rechciński, Tomasz, et al.
Publicado: (2022)

Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene
por: Bappy, Md. Nazmul Islam, et al.
Publicado: (2022)

In silico Evaluation of Nonsynonymous Single Nucleotide Polymorphisms in the ADIPOQ Gene Associated with Diabetes, Obesity, and Inflammation
por: Narayana Swamy, A, et al.
Publicado: (2015)

Genome-wide identification, evolution, and transcript profiling of Aldehyde dehydrogenase superfamily in potato during development stages and stress conditions
por: Islam, Md. Sifatul, et al.
Publicado: (2021)

Risk prediction and marker selection in nonsynonymous single nucleotide polymorphisms using whole genome sequencing data
por: Lee, Young-Sup, et al.
Publicado: (2020)

A Simulation Analysis and Screening of Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Sheep LEP Gene
por: Girmay, Shishay, et al.
Publicado: (2022)

Effect of Structural Changes in Proteins Derived from GATA4 Nonsynonymous Single Nucleotide Polymorphisms in Congenital Heart Disease
por: Manjegowda, D. S., et al.
Publicado: (2015)

Impacts of Nonsynonymous Single Nucleotide Polymorphisms of Adiponectin Receptor 1 Gene on Corresponding Protein Stability: A Computational Approach
por: Saleh, Md. Abu, et al.
Publicado: (2016)

Are Nonsynonymous Transversions Generally More Deleterious than Nonsynonymous Transitions?
por: Zou, Zhengting, et al.
Publicado: (2020)

Prediction of the Impact of Deleterious Nonsynonymous Single Nucleotide Polymorphisms on the Human RRM2B Gene: A Molecular Modeling Study
por: Ait El Cadi, Chaimaa, et al.
Publicado: (2020)

Prediction and Structural Comparison of Deleterious Coding Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Human LEP Gene Associated with Obesity
por: Bouafi, Hind, et al.
Publicado: (2019)

Predicting the Most Deleterious Missense Nonsynonymous Single-Nucleotide Polymorphisms of Hennekam Syndrome-Causing CCBE1 Gene, In Silico Analysis
por: Shinwari, Khyber, et al.
Publicado: (2021)

Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with Diseases
por: Sun, Bo, et al.
Publicado: (2015)

Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio‐informatics study
por: Coelho, Catarina, et al.
Publicado: (2019)

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose
por: Overway, Emily M., et al.
Publicado: (2021)

Investigation of hub genes and their nonsynonymous single nucleotide polymorphism analysis in Plasmodium falciparum for designing therapeutic methodologies using next-generation sequencing approach
por: Singh, Sanjay Kumar, et al.
Publicado: (2019)

Identification of potential drug targets by subtractive genome analysis of Escherichia coli O157:H7: an in silico approach
por: Mondal, Shakhinur Islam, et al.
Publicado: (2015)

The investigation of nonsynonymous SNPs of human SLC6A4 gene associated with depression: An in silico approach
por: Hasan, Md. Amit, et al.
Publicado: (2021)

A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes
por: Wenzlau, Janet M., et al.
Publicado: (2008)

Association between TNFAIP3 nonsynonymous single-nucleotide polymorphism rs2230926 and chronic hepatitis B virus infection in a Chinese Han population
por: Zhang, Pingping, et al.
Publicado: (2015)

Nonsynonymous Polymorphisms in the Human AS3MT Arsenic Methylation Gene: Implications for Arsenic Toxicity
por: Li, Jiaojiao, et al.
Publicado: (2017)

Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
por: Dash, Raju, et al.
Publicado: (2022)

Genome bioinformatic analysis of nonsynonymous SNPs
por: Burke, David F, et al.
Publicado: (2007)

When a Synonymous Variant Is Nonsynonymous
por: Vihinen, Mauno
Publicado: (2022)

Three Nonsynonymous Single Nucleotide Polymorphisms in the RhitH Gene Cause Reduction of the Repression Activity That Leads to Upregulation of M-LPH, a Participant in Mitochondrial Function
por: Iida, Reiko, et al.
Publicado: (2013)

Integrating Multiple Genomic Data to Predict Disease-Causing Nonsynonymous Single Nucleotide Variants in Exome Sequencing Studies
por: Wu, Jiaxin, et al.
Publicado: (2014)

Prioritization Of Nonsynonymous Single Nucleotide Variants For Exome Sequencing Studies Via Integrative Learning On Multiple Genomic Data
por: Wu, Mengmeng, et al.
Publicado: (2015)

Novel QTLs for salinity tolerance revealed by genome-wide association studies of biomass, chlorophyll and tissue ion content in 176 rice landraces from Bangladesh
por: Alam, Md Nafis Ul, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h1eg1ig1ik65n3019qqm2mjm18