S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies

The zinc finger antiviral protein (ZAP) is a broad inhibitor of virus replication. Its best-characterized function is to bind CpG dinucleotides present in viral RNAs and, through the recruitment of TRIM25, KHNYN and other cofactors, target them for degradation or prevent their translation. The long...

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Detalles Bibliográficos
Autores principales: Kmiec, Dorota, Lista, María José, Ficarelli, Mattia, Swanson, Chad M., Neil, Stuart J. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568172/
https://www.ncbi.nlm.nih.gov/pubmed/34695163
http://dx.doi.org/10.1371/journal.ppat.1009726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568172/
https://www.ncbi.nlm.nih.gov/pubmed/34695163
http://dx.doi.org/10.1371/journal.ppat.1009726

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