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M-DATA: A statistical approach to jointly analyzing de novo mutations for multiple traits

Recent studies have demonstrated that multiple early-onset diseases have shared risk genes, based on findings from de novo mutations (DNMs). Therefore, we may leverage information from one trait to improve statistical power to identify genes for another trait. However, there are few methods that can...

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Detalles Bibliográficos
Autores principales: Xie, Yuhan, Li, Mo, Dong, Weilai, Jiang, Wei, Zhao, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568192/
https://www.ncbi.nlm.nih.gov/pubmed/34735430
http://dx.doi.org/10.1371/journal.pgen.1009849