The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function

The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival. The ubiquitin-associated domain of SQSTM1/p62 is frequently mutated in patients with Paget’s disease of bone. Here, we...

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Detalles Bibliográficos
Autores principales: Sultana, Melanie A., Cluning, Carmel, Kwong, Wai-Sin, Polain, Nicole, Pavlos, Nathan J., Ratajczak, Thomas, Walsh, John P., Xu, Jiake, Rea, Sarah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568271/
https://www.ncbi.nlm.nih.gov/pubmed/34735553
http://dx.doi.org/10.1371/journal.pone.0259556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568271/
https://www.ncbi.nlm.nih.gov/pubmed/34735553
http://dx.doi.org/10.1371/journal.pone.0259556

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