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High-throughput screening to identify potential inhibitors of the Zα domain of the adenosine deaminase 1 (ADAR1)
Adenosine deaminases acting on RNA 1 (ADAR1) are enzymes involved in editing adenosine to inosine in the dsRNAs of cells associated with cancer development. The p150 isoform of ADAR1 is the only isoform containing the Zα domain that binds to both Z-DNA and Z-RNA. The Zα domain is suggested to modula...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568724/ https://www.ncbi.nlm.nih.gov/pubmed/34759749 http://dx.doi.org/10.1016/j.sjbs.2021.06.080 |