Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders

Mutations in glucocerebrosidase (GBA) are the most prevalent genetic risk factor for Lewy body disorders (LBD)—collectively Parkinson’s disease, Parkinson’s disease dementia and dementia with Lewy bodies. Despite this genetic association, it remains unclear how GBA mutations increase susceptibility...

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Detalles Bibliográficos
Autores principales: Kurzawa-Akanbi, Marzena, Tammireddy, Seshu, Fabrik, Ivo, Gliaudelytė, Lina, Doherty, Mary K., Heap, Rachel, Matečko-Burmann, Irena, Burmann, Björn M., Trost, Matthias, Lucocq, John M., Gherman, Anda V., Fairfoul, Graham, Singh, Preeti, Burté, Florence, Green, Alison, McKeith, Ian G., Härtlova, Anetta, Whitfield, Phillip D., Morris, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568874/
https://www.ncbi.nlm.nih.gov/pubmed/34514546
http://dx.doi.org/10.1007/s00401-021-02367-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568874/
https://www.ncbi.nlm.nih.gov/pubmed/34514546
http://dx.doi.org/10.1007/s00401-021-02367-3

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