Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation

Mutations of the mitochondrial genome (mtDNA) cause a range of profoundly debilitating clinical conditions for which treatment options are very limited. Most mtDNA diseases show heteroplasmy – tissues express both wild-type and mutant mtDNA. While the level of heteroplasmy broadly correlates with di...

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Detalles Bibliográficos
Autores principales: Chung, Chih-Yao, Singh, Kritarth, Kotiadis, Vassilios N., Valdebenito, Gabriel E., Ahn, Jee Hwan, Topley, Emilie, Tan, Joycelyn, Andrews, William D., Bilanges, Benoit, Pitceathly, Robert D. S., Szabadkai, Gyorgy, Yuneva, Mariia, Duchen, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568893/
https://www.ncbi.nlm.nih.gov/pubmed/34737295
http://dx.doi.org/10.1038/s41467-021-26746-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568893/
https://www.ncbi.nlm.nih.gov/pubmed/34737295
http://dx.doi.org/10.1038/s41467-021-26746-2

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