Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein

The cellular prion protein (PrP(C)) is a mainly α-helical 208-residue protein located in the pre- and postsynaptic membranes. For unknown reasons, PrP(C) can undergo a structural transition into a toxic, β-sheet rich scrapie isoform (PrP(Sc)) that is responsible for transmissible spongiform encephal...

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Detalles Bibliográficos
Autores principales: Gielnik, Maciej, Taube, Michał, Zhukova, Lilia, Zhukov, Igor, Wärmländer, Sebastian K. T. S., Svedružić, Željko, Kwiatek, Wojciech M., Gräslund, Astrid, Kozak, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568922/
https://www.ncbi.nlm.nih.gov/pubmed/34737343
http://dx.doi.org/10.1038/s41598-021-00495-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568922/
https://www.ncbi.nlm.nih.gov/pubmed/34737343
http://dx.doi.org/10.1038/s41598-021-00495-0

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