Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen

A major drawback of single-cell ATAC-seq (scATAC-seq) is its sparsity, i.e., open chromatin regions with no reads due to loss of DNA material during the scATAC-seq protocol. Here, we propose scOpen, a computational method based on regularized non-negative matrix factorization for imputing and quanti...

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Detalles Bibliográficos
Autores principales: Li, Zhijian, Kuppe, Christoph, Ziegler, Susanne, Cheng, Mingbo, Kabgani, Nazanin, Menzel, Sylvia, Zenke, Martin, Kramann, Rafael, Costa, Ivan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568974/
https://www.ncbi.nlm.nih.gov/pubmed/34737275
http://dx.doi.org/10.1038/s41467-021-26530-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568974/
https://www.ncbi.nlm.nih.gov/pubmed/34737275
http://dx.doi.org/10.1038/s41467-021-26530-2

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