Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

The transcriptional effector SMAD4 is a core component of the TGF-β family signaling pathways. However, its role in vertebrate embryo development remains unresolved. To address this, we deleted Smad4 in zebrafish and investigated the consequences of this on signaling by the TGF-β family morphogens,...

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Detalles Bibliográficos
Autores principales: Guglielmi, Luca, Heliot, Claire, Kumar, Sunil, Alexandrov, Yuriy, Gori, Ilaria, Papaleonidopoulou, Foteini, Barrington, Christopher, East, Philip, Economou, Andrew D., French, Paul M. W., McGinty, James, Hill, Caroline S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569018/
https://www.ncbi.nlm.nih.gov/pubmed/34737283
http://dx.doi.org/10.1038/s41467-021-26486-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569018/
https://www.ncbi.nlm.nih.gov/pubmed/34737283
http://dx.doi.org/10.1038/s41467-021-26486-3

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