Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition

The mechanistic target of rapamycin (mTOR) is a kinase whose activation is associated with poor prognosis in pre-B cell acute lymphoblastic leukemia (B-ALL). These and other findings have prompted diverse strategies for targeting mTOR signaling in B-ALL and other B-cell malignancies. In cellular mod...

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Detalles Bibliográficos
Autores principales: Vo, Thanh-Trang, Herzog, Lee-or, Buono, Roberta, Lee, Jong-Hoon Scott, Mallya, Sharmila, Duong, Madeleine R., Thao, Joshua, Gotesman, Moran, Fruman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569117/
https://www.ncbi.nlm.nih.gov/pubmed/34737376
http://dx.doi.org/10.1038/s41598-021-00950-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569117/
https://www.ncbi.nlm.nih.gov/pubmed/34737376
http://dx.doi.org/10.1038/s41598-021-00950-y

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