TGF-β1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction

p16 inhibits cyclin-dependent kinases and regulates senescence-mediated arrest as well as p21. Nuclear p16 promotes G1 cell cycle arrest and cellular senescence. In various glomerular diseases, nuclear p16 expression is associated with disease progression. Therefore, the location of p16 is important...

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Detalles Bibliográficos
Autores principales: Ueda, Sayo, Tominaga, Tatsuya, Ochi, Arisa, Sakurai, Akiko, Nishimura, Kenji, Shibata, Eriko, Wakino, Shu, Tamaki, Masanori, Nagai, Kojiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569175/
https://www.ncbi.nlm.nih.gov/pubmed/34737348
http://dx.doi.org/10.1038/s41598-021-01150-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569175/
https://www.ncbi.nlm.nih.gov/pubmed/34737348
http://dx.doi.org/10.1038/s41598-021-01150-4

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