Cargando…

Thrap3 promotes R-loop resolution via interaction with methylated DDX5

Transcription-replication conflicts lead to DNA damage and genomic instability, which are closely related to human diseases. A major source of these conflicts is the formation of R-loops, which consist of an RNA-DNA hybrid and a displaced single-stranded DNA. Although these structures have been stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Hyun Je, Eom, Hye-jin, Kim, Hongtae, Myung, Kyungjae, Kwon, Hyug Moo, Choi, Jang Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569202/ https://www.ncbi.nlm.nih.gov/pubmed/34697388 http://dx.doi.org/10.1038/s12276-021-00689-6

Ejemplares similares

TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution
por: Kang, Hyun Je, et al.
Publicado: (2020)

Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy
por: Jang, Hyun-Jun, et al.
Publicado: (2023)

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming
por: Choi, Jang Hyun, et al.
Publicado: (2014)

DDX17 helicase promotes resolution of R-loop-mediated transcription–replication conflicts in human cells
por: Boleslavska, Barbora, et al.
Publicado: (2022)

Cobll1: A new player in CML
por: Kim, Hongtae, et al.
Publicado: (2017)

Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity
por: Wang, Zhenguo, et al.
Publicado: (2021)

Identifying and characterising Thrap3, Bclaf1 and Erh interactions using cross-linking mass spectrometry
por: Shcherbakova, Liudmila, et al.
Publicado: (2023)

THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate
por: Polenkowski, Mareike, et al.
Publicado: (2022)

TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
por: Kang, Hyun Je, et al.
Publicado: (2019)

Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution
por: Villarreal, Oscar D, et al.
Publicado: (2020)

Clinical Response to Venetoclax and Decitabine in Acute Promyelocytic Leukemia With a Novel RARA-THRAP3 Fusion: A Case Report
por: Song, Baoquan, et al.
Publicado: (2022)

Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression
por: Byun, Seongjun, et al.
Publicado: (2022)

TonEBP Promotes β-Cell Survival under ER Stress by Enhancing Autophagy
por: Kang, Hyun Je, et al.
Publicado: (2020)

Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis
por: Lee, Jun Ho, et al.
Publicado: (2019)

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability
por: Mosler, Thorsten, et al.
Publicado: (2021)

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export
por: Vohhodina, Jekaterina, et al.
Publicado: (2017)

Helicases in R-loop Formation and Resolution
por: Yang, Shizhuo, et al.
Publicado: (2023)

Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca(2+) homeostasis
por: Choi, Sun Sil, et al.
Publicado: (2020)

The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132
por: Remenyi, Judit, et al.
Publicado: (2016)

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability
por: Song, Chenlin, et al.
Publicado: (2017)

DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions
por: Yu, Zhenbao, et al.
Publicado: (2020)

DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
por: Marchena-Cruz, Esther, et al.
Publicado: (2023)

Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids
por: Mersaoui, Sofiane Y, et al.
Publicado: (2019)

Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury
por: Yoo, Eun Jin, et al.
Publicado: (2019)

Knockdown of ZBTB11 impedes R‐loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancer
por: Chen, Lei, et al.
Publicado: (2022)

Hypoxia‐mediated regulation of DDX5 through decreased chromatin accessibility and post‐translational targeting restricts R‐loop accumulation
por: Leszczynska, Katarzyna B., et al.
Publicado: (2023)

Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia
por: Choi, Eun-Ji, et al.
Publicado: (2021)

DDX3 Upregulates Hydrogen Peroxide-Induced Melanogenesis in Sk-Mel-2 Human Melanoma Cells
por: Eom, Sanung, et al.
Publicado: (2022)

RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination
por: Ribeiro de Almeida, Claudia, et al.
Publicado: (2018)

UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
por: Pérez-Calero, Carmen, et al.
Publicado: (2020)

Enhancer-mediated enrichment of interacting JMJD3–DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription
por: Argaud, Deborah, et al.
Publicado: (2019)

Ring finger protein 126 (RNF126) suppresses ionizing radiation–induced p53-binding protein 1 (53BP1) focus formation
por: Lee, Nam Soo, et al.
Publicado: (2018)

ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork
por: Kim, Sangin, et al.
Publicado: (2020)

DDX3X and DDX3Y are redundant in protein synthesis
por: Venkataramanan, Srivats, et al.
Publicado: (2021)

TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1/Th17 responses
por: Ye, Byeong Jin, et al.
Publicado: (2020)

Effects and Prognostic Values of Circadian Genes CSNK1E/GNA11/KLF9/THRAP3 in Kidney Renal Clear Cell Carcinoma via a Comprehensive Analysis
por: Li, Shujing, et al.
Publicado: (2022)

R-loop resolution promotes co-transcriptional chromatin silencing
por: Xu, Congyao, et al.
Publicado: (2021)

DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
por: Xu, Kun, et al.
Publicado: (2022)

miR-429 Suppresses Endometrial Cancer Progression and Drug Resistance via DDX53
por: Lee, Kyung-Jun, et al.
Publicado: (2023)

TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
por: Yoo, Eun Jin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gj1l842fpic71g4ad6hfqcelpc