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Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine
We previously identified Alcaligenes spp. as a commensal bacterium that resides in lymphoid tissues, including Peyer’s patches. We found that Alcaligenes-derived lipopolysaccharide acted as a weak agonist of Toll-like receptor four due to the unique structure of lipid A, which lies in the core of li...
Autores principales: | Liu, Zilai, Hosomi, Koji, Shimoyama, Atsushi, Yoshii, Ken, Sun, Xiao, Lan, Huangwenxian, Wang, Yunru, Yamaura, Haruki, Kenneth, Davie, Saika, Azusa, Nagatake, Takahiro, Kiyono, Hiroshi, Fukase, Koichi, Kunisawa, Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569242/ https://www.ncbi.nlm.nih.gov/pubmed/34744743 http://dx.doi.org/10.3389/fphar.2021.763657 |
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