Aberrant Phase Separation of FUS Leads to Lysosome Sequestering and Acidification

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to the death of upper and lower motor neurons. While most cases of ALS are sporadic, some of the familial forms of the disease are caused by mutations in the gene encoding for the RNA-binding protein FUS. Under...

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Detalles Bibliográficos
Autores principales: Trnka, Franziska, Hoffmann, Christian, Wang, Han, Sansevrino, Roberto, Rankovic, Branislava, Rost, Benjamin R., Schmitz, Dietmar, Schmidt, H. Broder, Milovanovic, Dragomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569517/
https://www.ncbi.nlm.nih.gov/pubmed/34746121
http://dx.doi.org/10.3389/fcell.2021.716919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569517/
https://www.ncbi.nlm.nih.gov/pubmed/34746121
http://dx.doi.org/10.3389/fcell.2021.716919

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