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Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization

Posttranslational modifications (PTMs) such as phosphorylation of RNA-binding proteins (RBPs) regulate several critical steps in RNA metabolism, including spliceosome assembly, alternative splicing, and mRNA export. Notably, serine-/arginine- (SR)-rich RBPs are densely phosphorylated compared with t...

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Detalles Bibliográficos
Autores principales: Kundinger, Sean R., Dammer, Eric B., Yin, Luming, Hurst, Cheyenne, Shapley, Sarah, Ping, Lingyan, Khoshnevis, Sohail, Ghalei, Homa, Duong, Duc M., Seyfried, Nicholas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569591/
https://www.ncbi.nlm.nih.gov/pubmed/34673031
http://dx.doi.org/10.1016/j.jbc.2021.101306