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The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo
Cytokines are typically single gene products, except for the heterodimeric interleukin (IL)-12 family. The two subunits (IL-12p40 and IL-12p35) of the prototype IL-12 are known to be simultaneously co-expressed in activated myeloid cells, which secrete the fully active heterodimer to promote interfe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569637/ https://www.ncbi.nlm.nih.gov/pubmed/34644571 http://dx.doi.org/10.1016/j.celrep.2021.109816 |