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Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions

Topoisomerase 2 (TOP2) inhibitors are drugs widely used in the treatment of different types of cancer. Processing of their induced-lesions create double-strand breaks (DSBs) in the DNA, which is the main toxic mechanism of topoisomerase inhibitors to kill cancer cells. It was established that the Nu...

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Detalles Bibliográficos
Autores principales:	Busatto, Franciele Faccio, Mersaoui, Sofiane Y., Sun, Yilun, Pommier, Yves, Masson, Jean-Yves, Saffi, Jenifer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569893/ https://www.ncbi.nlm.nih.gov/pubmed/34746125 http://dx.doi.org/10.3389/fcell.2021.727836

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