The Role of Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis

Objective: High-dose methotrexate (HDMTX) is a mainstay therapeutic agent for the treatment of diverse hematological malignancies, and it plays a significant role in interindividual variability regarding the pharmacokinetics and toxicity. The genetic association of HDMTX has been widely investigated...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Zaiwei, Hu, Yang, Liu, Shuang, Jiang, Dan, Yi, Zhanmiao, Benjamin, Mason M., Zhao, Rongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570281/
https://www.ncbi.nlm.nih.gov/pubmed/34744734
http://dx.doi.org/10.3389/fphar.2021.757464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570281/
https://www.ncbi.nlm.nih.gov/pubmed/34744734
http://dx.doi.org/10.3389/fphar.2021.757464

Ejemplares similares