TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Age-associated neurodegenerative disorders demonstrating tau-laden intracellular inclusions are known as tauopathies. We previously linked a loss-of-function mutation in the TSC1 gene to tau accumulation and frontotemporal lobar degeneration. Now, we have identified genetic variants in TSC1 that dec...

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Detalles Bibliográficos
Autores principales: Alquezar, Carolina, Schoch, Kathleen M., Geier, Ethan G., Ramos, Eliana Marisa, Scrivo, Aurora, Li, Kathy H., Argouarch, Andrea R., Mlynarski, Elisabeth E., Dombroski, Beth, DeTure, Michael, Dickson, Dennis W., Yokoyama, Jennifer S., Cuervo, Ana M., Burlingame, Alma L., Schellenberg, Gerard D., Miller, Timothy M., Miller, Bruce L., Kao, Aimee W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570595/
https://www.ncbi.nlm.nih.gov/pubmed/34739309
http://dx.doi.org/10.1126/sciadv.abg3897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570595/
https://www.ncbi.nlm.nih.gov/pubmed/34739309
http://dx.doi.org/10.1126/sciadv.abg3897

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